UK Drug Discovery Initiative
       open forum for accelerating discovery and maximizing health benefits
Protein Structure    

about   people   meetings   partners   projects   facilities   funders   join   contact

Projects Funded

camseedCAMSEED: breast cancer drug discovery project focussed on calmodulin dependent Ser/Thr kinase
Coordinator: Michael Overduin, University of Birmingham and Peter Fischer, University of Nottingham
Funder: Wellcome Trust Seeding Drug Discovery Initiative

BBSRC CASEBBSRC Industrial Case PhD Studentship co-funded by AstraZeneca awarded to Lee Quill and Michael Overduin, University of Birmingham for NMR-based drug discovery on phosphatase targets

shpseedSHP-PDDI: juvenile myelomonocytic leukaemia project focussed on SHP phosphatase
Coordinator: Michael Overduin, University of Birmingham and Peter Fischer, University of Nottingham
Funder: Leukaemia & Lymphoma Research

MRCMRC-funded drug discoery project on a cardiac hypertropy and oncology target, PIs: Marc Lenoir and Michael Overduin, University of Birmingham.

Please let us know about additional projects coordinated by the members of this community.

Representative Publications

Mechanistic basis of desmosome-targeted diseases by Al-Jassar C, Bikker H, Overduin M, Chidgey M in J Mol Biol. 2013;425(21):4006-22. PMID: 23911551

Screening protein-small molecule interactions by NMR. by Davis B in Methods Mol Biol. 2013;1008:389-413. PMID: 23729260

Learning from our mistakes: the 'unknown knowns' in fragment screening by Davis BJ, Erlanson DA in Bioorg Med Chem Lett. 2013;23(10):2844-52. PMID: 23562240

Dual-specificity phosphatases as molecular targets for inhibition in human disease by Ros P, Nunes-Xavier CE, Tabernero L, Khn M, Pulido R in Antioxid Redox Signal. 2014;20(14):2251-73. PMID: 24206177

Targeting the disordered C terminus of PTP1B with an allosteric inhibitor by Krishnan N, Koveal D, Miller DH, Xue B, Akshinthala SD, Kragelj J, Jensen MR, Gauss CM, Page R, Blackledge M, Muthuswamy SK, Peti W, Tonks NK in Nat Chem Biol. 2014;10(7):558-66. PMID: 24845231

Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention
by Butterworth S, Overduin M, Barr AJ in Future Med Chem. 6(12):1423-37. PMID: 25329198

Discovery of novel membrane binding structures and functions by Kufareva I, Lenoir M, Dancea F, Sridhar P, Raush E, Bissig C, Gruenberg J, Abagyan R, Overduin M. in Biochem Cell Biol. 2014, PMID: 25394204